In pancreatic insufficiency, the pancreas is unable to produce enough digestive enzymes to appropriately digest food and therefore help facilitate proper nutrient absorption. It typically occurs as people age or can result from stress. In addition, conditions such as pancreatitis, diabetes, cystic fibrosis and cancer can lead to pancreatic insufficiency.

Symptoms of the disorder typically include malabsorption, malnutrition, vitamin deficiencies and weight loss or the inability to gain weight in children. Due to an inability to properly digest fats, a common symptom of pancreatic insufficiency is steatorrhea - loose, fatty, foul-smelling stools. High blood-sugar levels or poor blood-sugar control might also be a common symptom in adults.

Pancreatic insufficiency is best addressed when practitioners focus on therapies for underlying conditions to prevent further pancreatic damage. Digestive enzyme supplements are also necessary to support proper digestion. Enzymes help make up for decreased enzyme production and reduce stress on an already overstressed system. In addition, patients may be given vitamin supplements, especially fat-soluble vitamins A, D, E and K, since chronic pancreatitis is associated with lowered fat absorption. A diet low in fat and high in protein and calories might be recommended to help patients gain and maintain weight.